Role of Inflammation in Psychiatric Disease

Charles L Raison; Graham W. Rook; Andrew H. Miller; Tommy K. Begay

doi:10.1016/B978-0-12-398270-4.00026-4

Role of Inflammation in Psychiatric Disease

Charles L Raison, Graham W. Rook, Andrew H. Miller, Tommy K. Begay

Psychiatry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

11 Scopus citations

Abstract

This chapter is built on increasing evidence that individuals diagnosed with a wide range of currently recognized psychiatric diseases show significant increases in peripheral inflammatory biomarkers and CNS markers of immune activation, while simultaneously evincing reduced effectiveness of immune elements important for protection against pathogens. From this foundational assumption, a number of central unanswered questions regarding the relationship of immunity to emotional and cognitive functioning and behavior are explored. Tentative conclusions are reached that in addition to being impacted by mental events, immune activity may contribute to the development of a wide range of psychiatric disorders, and may tend to promote different disorders at different stages of the life course.

Original language	English (US)
Title of host publication	Neurobiology of Brain Disorders
Subtitle of host publication	Biological Basis of Neurological and Psychiatric Disorders
Publisher	Elsevier Inc.
Pages	396-421
Number of pages	26
ISBN (Electronic)	9780123982803
ISBN (Print)	9780123982704
DOIs	https://doi.org/10.1016/B978-0-12-398270-4.00026-4
State	Published - 2015

Keywords

Animal model
Autism
Cytokine
Immune
Inflammation
Interferon-
Major depression
Schizophrenia

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-398270-4.00026-4

Cite this

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title = "Role of Inflammation in Psychiatric Disease",

abstract = "This chapter is built on increasing evidence that individuals diagnosed with a wide range of currently recognized psychiatric diseases show significant increases in peripheral inflammatory biomarkers and CNS markers of immune activation, while simultaneously evincing reduced effectiveness of immune elements important for protection against pathogens. From this foundational assumption, a number of central unanswered questions regarding the relationship of immunity to emotional and cognitive functioning and behavior are explored. Tentative conclusions are reached that in addition to being impacted by mental events, immune activity may contribute to the development of a wide range of psychiatric disorders, and may tend to promote different disorders at different stages of the life course.",

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AU - Rook, Graham W.

AU - Miller, Andrew H.

AU - Begay, Tommy K.

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AB - This chapter is built on increasing evidence that individuals diagnosed with a wide range of currently recognized psychiatric diseases show significant increases in peripheral inflammatory biomarkers and CNS markers of immune activation, while simultaneously evincing reduced effectiveness of immune elements important for protection against pathogens. From this foundational assumption, a number of central unanswered questions regarding the relationship of immunity to emotional and cognitive functioning and behavior are explored. Tentative conclusions are reached that in addition to being impacted by mental events, immune activity may contribute to the development of a wide range of psychiatric disorders, and may tend to promote different disorders at different stages of the life course.

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KW - Autism

KW - Cytokine

KW - Immune

KW - Inflammation

KW - Interferon-

KW - Major depression

KW - Schizophrenia

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M3 - Chapter

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BT - Neurobiology of Brain Disorders

PB - Elsevier Inc.

ER -

Role of Inflammation in Psychiatric Disease

Abstract

Keywords

ASJC Scopus subject areas

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