Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp.

Han Wei; Ya Ming Xu; Patricia Espinosa-Artiles; Manping X. Liu; Jiang Guang Luo; Jana M. U'Ren; A. Elizabeth Arnold; A. A. Leslie Gunatilaka

doi:10.1016/j.phytochem.2015.08.010

Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp.

Han Wei, Ya Ming Xu, Patricia Espinosa-Artiles, Manping X. Liu, Jiang Guang Luo, Jana M. U'Ren, A. Elizabeth Arnold, A. A. Leslie Gunatilaka

Research output: Contribution to journal › Article › peer-review

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Abstract

Oxygenated guaiane-type sesquiterpenes, xylaguaianols A-D (1-4), an iso-cadinane-type sesquiterpene isocadinanol A (5), and an α-pyrone 9-hydroxyxylarone (6), together with five known sesquiterpenes (7-11), and four known cytochalasins (12-15) were isolated from a culture broth of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. The structures of all compounds were elucidated by the analysis of their spectroscopic data and relative configurations of 1-5 were determined with the help of NMR NOESY experiments. Cytochalasins C (12), D (13), and Q (14) were investigated for their cytotoxic activity against five tumor cell lines. Cytochalasin D showed significant cytotoxicity against all five cell lines, with IC₅₀s ranging from 0.22 to 1.44 μM, whereas cytochalasins C and Q exhibited moderate, but selective cytotoxicity.

Original language	English (US)
Pages (from-to)	102-108
Number of pages	7
Journal	Phytochemistry
Volume	118
DOIs	https://doi.org/10.1016/j.phytochem.2015.08.010
State	Published - Oct 1 2015

Keywords

Cytochalasins
Fungal endophyte
Hypnum sp.
Sesquiterpenes
Xylaguaianols
Xylaria sp.
α-Pyrone

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2015.08.010

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@article{880aecdb85b24e4ca1dada92d4d956b1,

title = "Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp.",

abstract = "Oxygenated guaiane-type sesquiterpenes, xylaguaianols A-D (1-4), an iso-cadinane-type sesquiterpene isocadinanol A (5), and an α-pyrone 9-hydroxyxylarone (6), together with five known sesquiterpenes (7-11), and four known cytochalasins (12-15) were isolated from a culture broth of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. The structures of all compounds were elucidated by the analysis of their spectroscopic data and relative configurations of 1-5 were determined with the help of NMR NOESY experiments. Cytochalasins C (12), D (13), and Q (14) were investigated for their cytotoxic activity against five tumor cell lines. Cytochalasin D showed significant cytotoxicity against all five cell lines, with IC50s ranging from 0.22 to 1.44 μM, whereas cytochalasins C and Q exhibited moderate, but selective cytotoxicity.",

keywords = "Cytochalasins, Fungal endophyte, Hypnum sp., Sesquiterpenes, Xylaguaianols, Xylaria sp., α-Pyrone",

author = "Han Wei and Xu, {Ya Ming} and Patricia Espinosa-Artiles and Liu, {Manping X.} and Luo, {Jiang Guang} and U'Ren, {Jana M.} and {Elizabeth Arnold}, A. and {Leslie Gunatilaka}, {A. A.}",

year = "2015",

month = oct,

day = "1",

doi = "10.1016/j.phytochem.2015.08.010",

language = "English (US)",

volume = "118",

pages = "102--108",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

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T1 - Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp.

AU - Wei, Han

AU - Xu, Ya Ming

AU - Espinosa-Artiles, Patricia

AU - Liu, Manping X.

AU - Luo, Jiang Guang

AU - U'Ren, Jana M.

AU - Elizabeth Arnold, A.

AU - Leslie Gunatilaka, A. A.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Oxygenated guaiane-type sesquiterpenes, xylaguaianols A-D (1-4), an iso-cadinane-type sesquiterpene isocadinanol A (5), and an α-pyrone 9-hydroxyxylarone (6), together with five known sesquiterpenes (7-11), and four known cytochalasins (12-15) were isolated from a culture broth of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. The structures of all compounds were elucidated by the analysis of their spectroscopic data and relative configurations of 1-5 were determined with the help of NMR NOESY experiments. Cytochalasins C (12), D (13), and Q (14) were investigated for their cytotoxic activity against five tumor cell lines. Cytochalasin D showed significant cytotoxicity against all five cell lines, with IC50s ranging from 0.22 to 1.44 μM, whereas cytochalasins C and Q exhibited moderate, but selective cytotoxicity.

AB - Oxygenated guaiane-type sesquiterpenes, xylaguaianols A-D (1-4), an iso-cadinane-type sesquiterpene isocadinanol A (5), and an α-pyrone 9-hydroxyxylarone (6), together with five known sesquiterpenes (7-11), and four known cytochalasins (12-15) were isolated from a culture broth of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. The structures of all compounds were elucidated by the analysis of their spectroscopic data and relative configurations of 1-5 were determined with the help of NMR NOESY experiments. Cytochalasins C (12), D (13), and Q (14) were investigated for their cytotoxic activity against five tumor cell lines. Cytochalasin D showed significant cytotoxicity against all five cell lines, with IC50s ranging from 0.22 to 1.44 μM, whereas cytochalasins C and Q exhibited moderate, but selective cytotoxicity.

KW - Cytochalasins

KW - Fungal endophyte

KW - Hypnum sp.

KW - Sesquiterpenes

KW - Xylaguaianols

KW - Xylaria sp.

KW - α-Pyrone

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M3 - Article

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SN - 0031-9422

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JO - Phytochemistry

JF - Phytochemistry

ER -

Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp.

Abstract

Keywords

ASJC Scopus subject areas

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