@article{1fdab3ee6dfa482caabceb887d2c86aa,
title = "Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death",
abstract = "Small-molecule targeting of the cooperative folding process in the hTERT G-quadruplex promoter element produces telomerase-independent events, which impair mitochondrial processes resulting in apoptotic cell death and inhibition of prostate cancer cell growth.",
keywords = "G-quadruplex, NRF2, ROS, docetaxel resistance, hTERT, oxidative stress, prostate cancer, telomerase",
author = "Song, {Jin H.} and Kang, {Hyun Jin} and Luevano, {Libia A.} and Vijay Gokhale and Kui Wu and Ritu Pandey and {Sherry Chow}, {H. H.} and Hurley, {Laurence H.} and Kraft, {Andrew S.}",
note = "Funding Information: The UACC Shared Resources provided support for histological and tissue staining, flow-cytometry analysis, and analytical chemistry. This study was supported by the University of Arizona Cancer Center support grant NIH P30CA023074 , NIH award R01CA173200 , and DOD award W81XWH-12-1-0560 (to A.S.K.), and by NIH awards R01CA177585 and R41CA224497 , and Reglagene (to L.H.H.). Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = aug,
day = "15",
doi = "10.1016/j.chembiol.2019.04.009",
language = "English (US)",
volume = "26",
pages = "1110--1121.e4",
journal = "Cell Chemical Biology",
issn = "2451-9456",
publisher = "Elsevier Inc.",
number = "8",
}