Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin

Nafees Ahmad; Shubh D. Sharma; Anil K. Rastogi; Jalil R. Kidwai; Krishna B. Mathur

doi:10.1007/BF02582090

Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin

Nafees Ahmad, Shubh D. Sharma, Anil K. Rastogi, Jalil R. Kidwai, Krishna B. Mathur

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two tetrapeptides, Glp-Met-Asp-Phe-NH₂ (I) and Pro-Met-Asp-Phe-NH₂ (II), analogous to the C-terminal tetrapeptide amide of cholecystokinin (CCK-4) have been synthesized and their effect on the release of insulin from the isolated Langerhans islets of rat pancreas compared with that of synthetic CCK-4. Both the new congeners exhibited significant insulin-releasing activity at 10^-8 M and 10^-6 M concentrations, suggesting that the biological activity is retained when the N-terminal Trp residue of CCK-4 is replaced by Glp or Pro.

Original language	English (US)
Pages (from-to)	361-364
Number of pages	4
Journal	Acta Diabetologica Latina
Volume	21
Issue number	4
DOIs	https://doi.org/10.1007/BF02582090
State	Published - Oct 1984

Keywords

C-terminal tetrapeptide amide
Cholecystokinin
Insulin secretion
Islets of Langerhans
Synthetic analogue

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/BF02582090

Cite this

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abstract = "Two tetrapeptides, Glp-Met-Asp-Phe-NH2 (I) and Pro-Met-Asp-Phe-NH2 (II), analogous to the C-terminal tetrapeptide amide of cholecystokinin (CCK-4) have been synthesized and their effect on the release of insulin from the isolated Langerhans islets of rat pancreas compared with that of synthetic CCK-4. Both the new congeners exhibited significant insulin-releasing activity at 10-8 M and 10-6 M concentrations, suggesting that the biological activity is retained when the N-terminal Trp residue of CCK-4 is replaced by Glp or Pro.",

keywords = "C-terminal tetrapeptide amide, Cholecystokinin, Insulin secretion, Islets of Langerhans, Synthetic analogue",

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AU - Ahmad, Nafees

AU - Sharma, Shubh D.

AU - Rastogi, Anil K.

AU - Kidwai, Jalil R.

AU - Mathur, Krishna B.

PY - 1984/10

Y1 - 1984/10

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AB - Two tetrapeptides, Glp-Met-Asp-Phe-NH2 (I) and Pro-Met-Asp-Phe-NH2 (II), analogous to the C-terminal tetrapeptide amide of cholecystokinin (CCK-4) have been synthesized and their effect on the release of insulin from the isolated Langerhans islets of rat pancreas compared with that of synthetic CCK-4. Both the new congeners exhibited significant insulin-releasing activity at 10-8 M and 10-6 M concentrations, suggesting that the biological activity is retained when the N-terminal Trp residue of CCK-4 is replaced by Glp or Pro.

KW - C-terminal tetrapeptide amide

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KW - Islets of Langerhans

KW - Synthetic analogue

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Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin

Abstract

Keywords

ASJC Scopus subject areas

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