Study quiescence heterogeneity by coupling single-cell measurements and computer modeling

Jungeun Sarah Kwon, Xia Wang, Guang Yao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Single-cell measurements combined with mathematical modeling and computer simulations are powerful tools for understanding and exploring dynamical behaviors of gene networks and cellular functions that they control. Here, we describe experimental and computational methods to study cellular quiescence and its heterogeneity at the single-cell level.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages287-299
Number of pages13
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1686

Keywords

  • Cell cycle
  • Click-iT EdU assay
  • DNA content
  • Deterministic simulation
  • Fluorescent protein reporter
  • Heterogeneity
  • Ordinary differential equation (ODE)
  • Quiescence
  • Stochastic simulation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint

Dive into the research topics of 'Study quiescence heterogeneity by coupling single-cell measurements and computer modeling'. Together they form a unique fingerprint.

Cite this