Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

Edita Navratilova; Frank Porreca

doi:10.1016/j.neuron.2019.01.034

Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

Edita Navratilova, Frank Porreca

Research output: Contribution to journal › Short survey › peer-review

40 Scopus citations

Abstract

How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.

Original language	English (US)
Pages (from-to)	353-355
Number of pages	3
Journal	Neuron
Volume	101
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2019.01.034
State	Published - Feb 6 2019

Keywords

MrgprB2 receptor
NK1 receptor
mast cells
neuroinflammation
pain
substance P

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2019.01.034

Cite this

@article{d1a44097f8284e329e3e548e588ce287,

title = "Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously",

abstract = "How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.",

keywords = "MrgprB2 receptor, NK1 receptor, mast cells, neuroinflammation, pain, substance P",

author = "Edita Navratilova and Frank Porreca",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = feb,

day = "6",

doi = "10.1016/j.neuron.2019.01.034",

language = "English (US)",

volume = "101",

pages = "353--355",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Substance P and Inflammatory Pain

T2 - Getting It Wrong and Right Simultaneously

AU - Navratilova, Edita

AU - Porreca, Frank

PY - 2019/2/6

Y1 - 2019/2/6

N2 - How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.

AB - How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.

KW - MrgprB2 receptor

KW - NK1 receptor

KW - mast cells

KW - neuroinflammation

KW - pain

KW - substance P

UR - http://www.scopus.com/inward/record.url?scp=85060442246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060442246&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2019.01.034

DO - 10.1016/j.neuron.2019.01.034

M3 - Short survey

C2 - 30731054

SN - 0896-6273

VL - 101

SP - 353

EP - 355

JO - Neuron

JF - Neuron

IS - 3

ER -

Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this