Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Haiying Sun; Gaddam Bapu Reddy; Clifford George; Emmanuelle J. Meuillet; Margareta Berggren; Garth Powis; Alan P. Kozikowski

doi:10.1016/S0040-4039(02)00354-4

Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Haiying Sun
, Gaddam Bapu Reddy
, Clifford George
, Emmanuelle J. Meuillet
, Margareta Berggren
, Garth Powis
, Alan P. Kozikowski

Nutritional Sci Wellness - RES

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

Original language	English (US)
Pages (from-to)	2835-2838
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	15
DOIs	https://doi.org/10.1016/S0040-4039(02)00354-4
State	Published - Apr 8 2002

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(02)00354-4

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title = "Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues",

abstract = "Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.",

author = "Haiying Sun and \{Bapu Reddy\}, Gaddam and Clifford George and Meuillet, \{Emmanuelle J.\} and Margareta Berggren and Garth Powis and Kozikowski, \{Alan P.\}",

note = "Funding Information: We thank the National Institutes of Health (Grant CA61015) for support of this research.",

year = "2002",

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doi = "10.1016/S0040-4039(02)00354-4",

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T1 - Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

AU - Sun, Haiying

AU - Bapu Reddy, Gaddam

AU - George, Clifford

AU - Meuillet, Emmanuelle J.

AU - Berggren, Margareta

AU - Powis, Garth

AU - Kozikowski, Alan P.

N1 - Funding Information: We thank the National Institutes of Health (Grant CA61015) for support of this research.

PY - 2002/4/8

Y1 - 2002/4/8

N2 - Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

AB - Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

UR - https://www.scopus.com/pages/publications/0037041364

UR - https://www.scopus.com/pages/publications/0037041364#tab=citedBy

U2 - 10.1016/S0040-4039(02)00354-4

DO - 10.1016/S0040-4039(02)00354-4

M3 - Article

SN - 0040-4039

VL - 43

SP - 2835

EP - 2838

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 15

ER -

Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Abstract

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CCDC 186081: Experimental Crystal Structure Determination

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Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Abstract

ASJC Scopus subject areas

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Datasets

CCDC 186081: Experimental Crystal Structure Determination

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