[Tc-99m]-sestamibi uptake and washout in locally advanced breast cancer are correlated with tumor blood flow

David A. Mankoff; Lisa K. Dunnwald; Julie R. Gralow; Georgiana K. Ellis; Erin K. Schubert; Aaron W. Charlop; Jeffrey Tseng; Kristine J. Rinn; Robert B. Livingston

doi:10.1016/S0969-8051(02)00333-5

[Tc-99m]-sestamibi uptake and washout in locally advanced breast cancer are correlated with tumor blood flow

David A. Mankoff, Lisa K. Dunnwald, Julie R. Gralow, Georgiana K. Ellis, Erin K. Schubert, Aaron W. Charlop, Jeffrey Tseng, Kristine J. Rinn, Robert B. Livingston

Cancer Center

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Objectives: To determine the influence of breast tumor blood flow on MIBI kinetics, we compared MIBI uptake and washout to [O-15]-water PET estimates of blood flow in patients with locally advanced breast cancer. Methods: Prior to therapy, 37 patients underwent MIBI and [O-15]-water PET imaging; 22/37 also had MIBI washout analysis. Twenty-five patients underwent serial imaging over the course of chemotherapy. Results: MIBI uptake and blood flow had a significant positive correlation pre-therapy. The change in MIBI uptake over the course of therapy also correlated with the change in blood flow. The half-time of MIBI washout inversely correlated with blood flow, indicating faster MIBI washout with higher blood flow. Conclusions: Blood flow strongly influences early MIBI uptake and can be a factor affecting the rate of MIBI washout in breast tumors. We present a model of MIBI kinetics in tumors which forms a hypothesis for further mechanistic studies of MIBI uptake and washout in breast cancer.

Original language	English (US)
Pages (from-to)	719-727
Number of pages	9
Journal	Nuclear Medicine and Biology
Volume	29
Issue number	7
DOIs	https://doi.org/10.1016/S0969-8051(02)00333-5
State	Published - Oct 2002

Keywords

Blood flow
Breast cancer
MIBI
Mechanisms
PET
Tumor imaging

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/S0969-8051(02)00333-5

Cite this

@article{cb9dec0d9bcc4fffbf54781901d13cfb,

title = "[Tc-99m]-sestamibi uptake and washout in locally advanced breast cancer are correlated with tumor blood flow",

abstract = "Objectives: To determine the influence of breast tumor blood flow on MIBI kinetics, we compared MIBI uptake and washout to [O-15]-water PET estimates of blood flow in patients with locally advanced breast cancer. Methods: Prior to therapy, 37 patients underwent MIBI and [O-15]-water PET imaging; 22/37 also had MIBI washout analysis. Twenty-five patients underwent serial imaging over the course of chemotherapy. Results: MIBI uptake and blood flow had a significant positive correlation pre-therapy. The change in MIBI uptake over the course of therapy also correlated with the change in blood flow. The half-time of MIBI washout inversely correlated with blood flow, indicating faster MIBI washout with higher blood flow. Conclusions: Blood flow strongly influences early MIBI uptake and can be a factor affecting the rate of MIBI washout in breast tumors. We present a model of MIBI kinetics in tumors which forms a hypothesis for further mechanistic studies of MIBI uptake and washout in breast cancer.",

keywords = "Blood flow, Breast cancer, MIBI, Mechanisms, PET, Tumor imaging",

author = "Mankoff, {David A.} and Dunnwald, {Lisa K.} and Gralow, {Julie R.} and Ellis, {Georgiana K.} and Schubert, {Erin K.} and Charlop, {Aaron W.} and Jeffrey Tseng and Rinn, {Kristine J.} and Livingston, {Robert B.}",

note = "Funding Information: This work was supported by NIH grant RO1 CA72064, P01 CA42045 and a grant from DuPont Pharmaceuticals. The authors wish to thank Barbara Lewellen, Pam Pham, and the other University of Washington Nuclear Medicine Technologists for technical assistance with image acquisition and the University of Washington Radoichemistry group for [O-15]-water product. The authors also wish to thank Drs. Janet Eary and Kenneth Krohn for helpful comments. Funding Information: Supported by NIH Grants CA72064 and CA42045 and a grant from DuPont Pharma.",

year = "2002",

month = oct,

doi = "10.1016/S0969-8051(02)00333-5",

language = "English (US)",

volume = "29",

pages = "719--727",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - [Tc-99m]-sestamibi uptake and washout in locally advanced breast cancer are correlated with tumor blood flow

AU - Mankoff, David A.

AU - Dunnwald, Lisa K.

AU - Gralow, Julie R.

AU - Ellis, Georgiana K.

AU - Schubert, Erin K.

AU - Charlop, Aaron W.

AU - Tseng, Jeffrey

AU - Rinn, Kristine J.

AU - Livingston, Robert B.

N1 - Funding Information: This work was supported by NIH grant RO1 CA72064, P01 CA42045 and a grant from DuPont Pharmaceuticals. The authors wish to thank Barbara Lewellen, Pam Pham, and the other University of Washington Nuclear Medicine Technologists for technical assistance with image acquisition and the University of Washington Radoichemistry group for [O-15]-water product. The authors also wish to thank Drs. Janet Eary and Kenneth Krohn for helpful comments. Funding Information: Supported by NIH Grants CA72064 and CA42045 and a grant from DuPont Pharma.

PY - 2002/10

Y1 - 2002/10

N2 - Objectives: To determine the influence of breast tumor blood flow on MIBI kinetics, we compared MIBI uptake and washout to [O-15]-water PET estimates of blood flow in patients with locally advanced breast cancer. Methods: Prior to therapy, 37 patients underwent MIBI and [O-15]-water PET imaging; 22/37 also had MIBI washout analysis. Twenty-five patients underwent serial imaging over the course of chemotherapy. Results: MIBI uptake and blood flow had a significant positive correlation pre-therapy. The change in MIBI uptake over the course of therapy also correlated with the change in blood flow. The half-time of MIBI washout inversely correlated with blood flow, indicating faster MIBI washout with higher blood flow. Conclusions: Blood flow strongly influences early MIBI uptake and can be a factor affecting the rate of MIBI washout in breast tumors. We present a model of MIBI kinetics in tumors which forms a hypothesis for further mechanistic studies of MIBI uptake and washout in breast cancer.

AB - Objectives: To determine the influence of breast tumor blood flow on MIBI kinetics, we compared MIBI uptake and washout to [O-15]-water PET estimates of blood flow in patients with locally advanced breast cancer. Methods: Prior to therapy, 37 patients underwent MIBI and [O-15]-water PET imaging; 22/37 also had MIBI washout analysis. Twenty-five patients underwent serial imaging over the course of chemotherapy. Results: MIBI uptake and blood flow had a significant positive correlation pre-therapy. The change in MIBI uptake over the course of therapy also correlated with the change in blood flow. The half-time of MIBI washout inversely correlated with blood flow, indicating faster MIBI washout with higher blood flow. Conclusions: Blood flow strongly influences early MIBI uptake and can be a factor affecting the rate of MIBI washout in breast tumors. We present a model of MIBI kinetics in tumors which forms a hypothesis for further mechanistic studies of MIBI uptake and washout in breast cancer.

KW - Blood flow

KW - Breast cancer

KW - MIBI

KW - Mechanisms

KW - PET

KW - Tumor imaging

UR - http://www.scopus.com/inward/record.url?scp=0036792109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036792109&partnerID=8YFLogxK

U2 - 10.1016/S0969-8051(02)00333-5

DO - 10.1016/S0969-8051(02)00333-5

M3 - Article

C2 - 12381452

SN - 0969-8051

VL - 29

SP - 719

EP - 727

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 7

ER -

[Tc-99m]-sestamibi uptake and washout in locally advanced breast cancer are correlated with tumor blood flow

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this