TY - JOUR
T1 - The biology of aging in a social world
T2 - Insights from free-ranging rhesus macaques
AU - Newman, Laura E.
AU - Testard, Camille
AU - DeCasien, Alex R.
AU - Chiou, Kenneth L.
AU - Watowich, Marina M.
AU - Janiak, Mareike C.
AU - Pavez-Fox, Melissa A.
AU - Sanchez Rosado, Mitchell R.
AU - Cooper, Eve B.
AU - Costa, Christina E.
AU - Petersen, Rachel M.
AU - Unit, Cayo Biobank Research
AU - Montague, Michael J.
AU - Platt, Michael L.
AU - Brent, Lauren J.N.
AU - Snyder-Mackler, Noah
AU - Higham, James P.
N1 - Publisher Copyright: © 2023 Elsevier Ltd
PY - 2023/11
Y1 - 2023/11
N2 - Social adversity can increase the age-associated risk of disease and death, yet the biological mechanisms that link social adversities to aging remain poorly understood. Long-term naturalistic studies of nonhuman animals are crucial for integrating observations of social behavior throughout an individual's life with detailed anatomical, physiological, and molecular measurements. Here, we synthesize the body of research from one such naturalistic study system, Cayo Santiago, which is home to the world's longest continuously monitored free-ranging population of rhesus macaques (Macaca mulatta). We review recent studies of age-related variation in morphology, gene regulation, microbiome composition, and immune function. We also discuss ecological and social modifiers of age-markers in this population. In particular, we summarize how a major natural disaster, Hurricane Maria, affected rhesus macaque physiology and social structure and highlight the context-dependent and domain-specific nature of aging modifiers. Finally, we conclude by providing directions for future study, on Cayo Santiago and elsewhere, that will further our understanding of aging across different domains and how social adversity modifies aging processes.
AB - Social adversity can increase the age-associated risk of disease and death, yet the biological mechanisms that link social adversities to aging remain poorly understood. Long-term naturalistic studies of nonhuman animals are crucial for integrating observations of social behavior throughout an individual's life with detailed anatomical, physiological, and molecular measurements. Here, we synthesize the body of research from one such naturalistic study system, Cayo Santiago, which is home to the world's longest continuously monitored free-ranging population of rhesus macaques (Macaca mulatta). We review recent studies of age-related variation in morphology, gene regulation, microbiome composition, and immune function. We also discuss ecological and social modifiers of age-markers in this population. In particular, we summarize how a major natural disaster, Hurricane Maria, affected rhesus macaque physiology and social structure and highlight the context-dependent and domain-specific nature of aging modifiers. Finally, we conclude by providing directions for future study, on Cayo Santiago and elsewhere, that will further our understanding of aging across different domains and how social adversity modifies aging processes.
KW - Aging
KW - Cayo Santiago
KW - Primate
KW - Senescence
KW - Social behavior
UR - http://www.scopus.com/inward/record.url?scp=85174744718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85174744718&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2023.105424
DO - 10.1016/j.neubiorev.2023.105424
M3 - Review article
C2 - 37827475
SN - 0149-7634
VL - 154
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 105424
ER -