The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips

Cong Zhao; Rui Xu; Kui Song; Dayu Liu; Shuo Ma; Chen Tang; Chun Liang; Yitshak Zohar; Yi Kuen Lee

doi:10.1109/MEMSYS.2015.7050989

The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips

Cong Zhao, Rui Xu, Kui Song, Dayu Liu, Shuo Ma, Chen Tang, Chun Liang, Yitshak Zohar, Yi Kuen Lee

Research output: Contribution to journal › Conference article › peer-review

3 Scopus citations

Abstract

We present a systematic study of the Capillary number (Ca) effect on the capture efficiency of cancer cells on a composite microfluidic filtration chip. By altering the Ca in microchip experiments, the balance between the viscous force and the cell cortical tension affecting the capture efficiency has been investigated experimentally and analyzed theoretically. A 'Phase Diagram' for the capture efficiency of microfiltration chips is presented, for the first time, as a function of the normalized cell diameter and Ca. A critical value of Ca, around 0.03∼0.04, has been identified for enhancing the capture efficiency of cancer cells. The phase diagram is found to be consistent with the results of cancer-cell capture in microfiltration systems reported previously by others. The diagram can be a useful tool for designing the next generation microfiltration devices for isolating circulating tumor cells.

Original language	English (US)
Article number	7050989
Pages (from-to)	459-462
Number of pages	4
Journal	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2015-February
Issue number	February
DOIs	https://doi.org/10.1109/MEMSYS.2015.7050989
State	Published - Feb 26 2015
Event	2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 - Estoril, Portugal Duration: Jan 18 2015 → Jan 22 2015

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

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10.1109/MEMSYS.2015.7050989

Cite this

Zhao, C., Xu, R., Song, K., Liu, D., Ma, S., Tang, C., Liang, C., Zohar, Y., & Lee, Y. K. (2015). The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 2015-February(February), 459-462. Article 7050989. https://doi.org/10.1109/MEMSYS.2015.7050989

The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips. / Zhao, Cong; Xu, Rui; Song, Kui et al.
In: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Vol. 2015-February, No. February, 7050989, 26.02.2015, p. 459-462.

Research output: Contribution to journal › Conference article › peer-review

Zhao, C, Xu, R, Song, K, Liu, D, Ma, S, Tang, C, Liang, C, Zohar, Y & Lee, YK 2015, 'The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips', Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2015-February, no. February, 7050989, pp. 459-462. https://doi.org/10.1109/MEMSYS.2015.7050989

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abstract = "We present a systematic study of the Capillary number (Ca) effect on the capture efficiency of cancer cells on a composite microfluidic filtration chip. By altering the Ca in microchip experiments, the balance between the viscous force and the cell cortical tension affecting the capture efficiency has been investigated experimentally and analyzed theoretically. A 'Phase Diagram' for the capture efficiency of microfiltration chips is presented, for the first time, as a function of the normalized cell diameter and Ca. A critical value of Ca, around 0.03∼0.04, has been identified for enhancing the capture efficiency of cancer cells. The phase diagram is found to be consistent with the results of cancer-cell capture in microfiltration systems reported previously by others. The diagram can be a useful tool for designing the next generation microfiltration devices for isolating circulating tumor cells.",

author = "Cong Zhao and Rui Xu and Kui Song and Dayu Liu and Shuo Ma and Chen Tang and Chun Liang and Yitshak Zohar and Lee, {Yi Kuen}",

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The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips

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