The epigenetics of Alzheimer's disease - additional considerations

Joseph Rogers; Diego Mastroeni; Andrew Grover; Elaine Delvaux; Charisse Whiteside; Paul D. Coleman

doi:10.1016/j.neurobiolaging.2011.02.025

The epigenetics of Alzheimer's disease - additional considerations

Joseph Rogers, Diego Mastroeni, Andrew Grover, Elaine Delvaux, Charisse Whiteside, Paul D. Coleman

Research output: Contribution to journal › Comment/debate › peer-review

8 Scopus citations

Abstract

The critical commentaries following our review of the epigenetics of Alzheimer's disease (AD) amplify a number of key points with respect to the role of 1-carbon metabolism, the phenomenon of allele-specific methylation, the potentially critical explanatory link provided by epigenetic mechanisms for genome-wide association and large-scale gene expression array studies, and new therapeutic approaches afforded by epigenetic manipulation in Alzheimer's disease.

Original language	English (US)
Pages (from-to)	1196-1197
Number of pages	2
Journal	Neurobiology of Aging
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.02.025
State	Published - Jul 2011
Externally published	Yes

Keywords

Aging
Alzheimer's disease
DNA methylation
Epigenetics
Histone marks
MiRNA

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2011.02.025

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title = "The epigenetics of Alzheimer's disease - additional considerations",

abstract = "The critical commentaries following our review of the epigenetics of Alzheimer's disease (AD) amplify a number of key points with respect to the role of 1-carbon metabolism, the phenomenon of allele-specific methylation, the potentially critical explanatory link provided by epigenetic mechanisms for genome-wide association and large-scale gene expression array studies, and new therapeutic approaches afforded by epigenetic manipulation in Alzheimer's disease.",

keywords = "Aging, Alzheimer's disease, DNA methylation, Epigenetics, Histone marks, MiRNA",

author = "Joseph Rogers and Diego Mastroeni and Andrew Grover and Elaine Delvaux and Charisse Whiteside and Coleman, {Paul D.}",

note = "Funding Information: Preparation of this report was supported by NIA AGO-7367-19 (JR), NIA AG 036400 (PC), and the Arizona Alzheimer's Disease Consortium (JR, AG).",

year = "2011",

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journal = "Neurobiology of Aging",

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T1 - The epigenetics of Alzheimer's disease - additional considerations

AU - Rogers, Joseph

AU - Mastroeni, Diego

AU - Grover, Andrew

AU - Delvaux, Elaine

AU - Whiteside, Charisse

AU - Coleman, Paul D.

N1 - Funding Information: Preparation of this report was supported by NIA AGO-7367-19 (JR), NIA AG 036400 (PC), and the Arizona Alzheimer's Disease Consortium (JR, AG).

PY - 2011/7

Y1 - 2011/7

N2 - The critical commentaries following our review of the epigenetics of Alzheimer's disease (AD) amplify a number of key points with respect to the role of 1-carbon metabolism, the phenomenon of allele-specific methylation, the potentially critical explanatory link provided by epigenetic mechanisms for genome-wide association and large-scale gene expression array studies, and new therapeutic approaches afforded by epigenetic manipulation in Alzheimer's disease.

AB - The critical commentaries following our review of the epigenetics of Alzheimer's disease (AD) amplify a number of key points with respect to the role of 1-carbon metabolism, the phenomenon of allele-specific methylation, the potentially critical explanatory link provided by epigenetic mechanisms for genome-wide association and large-scale gene expression array studies, and new therapeutic approaches afforded by epigenetic manipulation in Alzheimer's disease.

KW - Aging

KW - Alzheimer's disease

KW - DNA methylation

KW - Epigenetics

KW - Histone marks

KW - MiRNA

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DO - 10.1016/j.neurobiolaging.2011.02.025

M3 - Comment/debate

C2 - 21497949

SN - 0197-4580

VL - 32

SP - 1196

EP - 1197

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 7

ER -

The epigenetics of Alzheimer's disease - additional considerations

Abstract

Keywords

ASJC Scopus subject areas

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