TY - JOUR
T1 - The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation
AU - Rahim, Tania
AU - Levinson, Madison A.
AU - Carufe, Kelly E.W.
AU - Burak, Matthew
AU - Meas, Rithy
AU - Maher, Stephen
AU - Bothwell, Alfred L.M.
AU - Gades, Naomi
AU - Sweasy, Joann B.
N1 - Publisher Copyright: © 2022 Rahim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
PY - 2022/4
Y1 - 2022/4
N2 - Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We previously showed that the POLBY265C/C mutation, which results in development of an aberrant immune repertoire, leads to lupus-like disease in mice. To address whether the hematopoietic compartment is sufficient for lupus development, we transplanted bone marrow cells from POLBY265C/C and POLB+/+ into wild-type congenic mice. Only mice transplanted with the POLBY265C/C bone marrow develop high levels of antinuclear antibodies and renal disease. In conclusion, we show that the hematopoietic compartment harvested from the POLBY265C/C mice is sufficient for development of autoimmune disease.
AB - Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development. We previously showed that the POLBY265C/C mutation, which results in development of an aberrant immune repertoire, leads to lupus-like disease in mice. To address whether the hematopoietic compartment is sufficient for lupus development, we transplanted bone marrow cells from POLBY265C/C and POLB+/+ into wild-type congenic mice. Only mice transplanted with the POLBY265C/C bone marrow develop high levels of antinuclear antibodies and renal disease. In conclusion, we show that the hematopoietic compartment harvested from the POLBY265C/C mice is sufficient for development of autoimmune disease.
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U2 - 10.1371/journal.pone.0267913
DO - 10.1371/journal.pone.0267913
M3 - Article
C2 - 35486639
SN - 1932-6203
VL - 17
JO - PloS one
JF - PloS one
IS - 4 April
M1 - e0267913
ER -