The inheritance of immunoglobulin E: Genetic linkage analysis

D. A. Meyers; S. J. Hasstedt; D. G. Marsh; M. Skolnick; M. C. King; W. B. Bias; D. B. Amos

doi:10.1002/ajmg.1320160414

The inheritance of immunoglobulin E: Genetic linkage analysis

D. A. Meyers, S. J. Hasstedt, D. G. Marsh, M. Skolnick, M. C. King, W. B. Bias, D. B. Amos

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Abstract

Linkage analyses between 21 genetic markers including HLA-A, B, and the postulated locus for determining total serum IgE levels were done to try to clarify the inheritance of total IgE levels and to map the locus. A total of 316 individuals from five Mormon kindreds were studied, and data from an additional 204 Amish individuals from 11 families were analyzed for possible HLA linkage. Segregation analyses of both data sets did not give clear definition of the mode of inheritance of total IgE levels, but purely environmental models were rejected. Linkage analyses gave significant evidence against HLA linkage with the codominant, recessive, or dominant model of inheritance for total IgE levels. No significant evidence for linkage with any of the genetic markers was obtained. Since total serum IgE levels are correlated with allergies, understanding the genetics of total IgE levels is important to understanding the genetics of allergic disease in man.

Original language	English (US)
Pages (from-to)	575-581
Number of pages	7
Journal	American journal of medical genetics
Volume	16
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.1320160414
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)

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title = "The inheritance of immunoglobulin E: Genetic linkage analysis",

abstract = "Linkage analyses between 21 genetic markers including HLA-A, B, and the postulated locus for determining total serum IgE levels were done to try to clarify the inheritance of total IgE levels and to map the locus. A total of 316 individuals from five Mormon kindreds were studied, and data from an additional 204 Amish individuals from 11 families were analyzed for possible HLA linkage. Segregation analyses of both data sets did not give clear definition of the mode of inheritance of total IgE levels, but purely environmental models were rejected. Linkage analyses gave significant evidence against HLA linkage with the codominant, recessive, or dominant model of inheritance for total IgE levels. No significant evidence for linkage with any of the genetic markers was obtained. Since total serum IgE levels are correlated with allergies, understanding the genetics of total IgE levels is important to understanding the genetics of allergic disease in man.",

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T2 - Genetic linkage analysis

AU - Meyers, D. A.

AU - Hasstedt, S. J.

AU - Marsh, D. G.

AU - Skolnick, M.

AU - King, M. C.

AU - Bias, W. B.

AU - Amos, D. B.

PY - 1983

Y1 - 1983

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AB - Linkage analyses between 21 genetic markers including HLA-A, B, and the postulated locus for determining total serum IgE levels were done to try to clarify the inheritance of total IgE levels and to map the locus. A total of 316 individuals from five Mormon kindreds were studied, and data from an additional 204 Amish individuals from 11 families were analyzed for possible HLA linkage. Segregation analyses of both data sets did not give clear definition of the mode of inheritance of total IgE levels, but purely environmental models were rejected. Linkage analyses gave significant evidence against HLA linkage with the codominant, recessive, or dominant model of inheritance for total IgE levels. No significant evidence for linkage with any of the genetic markers was obtained. Since total serum IgE levels are correlated with allergies, understanding the genetics of total IgE levels is important to understanding the genetics of allergic disease in man.

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The inheritance of immunoglobulin E: Genetic linkage analysis

Abstract

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