@article{211b405c956340439f2091b8b2636ce6,
title = "The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation",
abstract = "In an important sense, support of the respiratory system has been a defining characteristic of intensive care since its inception. The pace of basic and clinical research in this field has escalated over the past two decades, resulting in palpable improvement at the bedside as measured by both efficacy and outcome. As in all medical research, however, novel ideas built upon observations are continually proposed, tested, and either retained or discarded on the basis of the persuasiveness of the evidence. What follows are concise descriptions of the current standards of management practice in respiratory support, the areas of present-day uncertainty, and our suggested agenda for the near future of research aimed at testing current assumptions, probing uncertainties, and solidifying the foundation on which to base our progress to the next level.",
keywords = "Acute respiratory failure, Airways, Intubation, Mechanical ventilation, Non-invasive ventilation, Weaning",
author = "Samir Jaber and Giacomo Bellani and Lluis Blanch and Alexandre Demoule and Andr{\'e}s Esteban and Luciano Gattinoni and Claude Gu{\'e}rin and Nicholas Hill and Laffey, {John G.} and Maggiore, {Salvatore Maurizio} and Jordi Mancebo and Mayo, {Paul H.} and Mosier, {Jarrod M.} and Paolo Navalesi and Michael Quintel and Vincent, {Jean Louis} and Marini, {John J.}",
note = "Funding Information: Dr Blanch is inventor of a US patent owned by Corporaci{\'o} Sanitaria Parc Taul{\'i}: “Method and system for managing related patient parameters provided by a monitoring device,” US Patent No. 12/538,940. He owns stock options in BetterCare S.L., a research and development start-up of Corporaci{\'o} Sanit{\`a}ria Parc Taul{\'i} (Spain). Dr Demoule reports personal fees from Maquet, grants, personal fees, and non-financial support from Covidien, personal fees from MSD, grants and non-financial support from Philips, non-financial support from Drager, grants from Resmed, and personal fees from Fisher and Paykel, all outside the submitted work. Dr Jaber reports receiving consulting fees from Drager, Hamilton, Maquet, and Fisher and Paykel. Dr Maggiore is the principal investigator of the RINO trial (nasal high-flow vs Venturi mask after extubation), sponsored by Fisher and Paykel Healthcare, and has received research grants from Fisher and Paykel Healthcare and lecture fees from Draeger Medical and GE Healthcare. Dr Mancebo reports the following: Covidien and Maquet—research support; Faron—steering committee member; Covidien and Hamilton—honoraria for speaking at a meeting. Dr. Navalesi{\textquoteright}s research laboratory has received equipment and grants from Maquet Critical Care, Draeger, and Intersurgical S.p.A. He has also received honoraria/speaking fees from Maquet Critical Care, Draeger, Breas, Philips, Resmed, and Hillrom. Dr Navalesi contributed to the development of the helmet Next, whose license for patent belongs to Intersurgical S.p.A., and receives royalties for that invention. Dr Quintel acts as advisor for Xenios and Baxter. CG, JGL, JJM, JMM, PM, and JLV declare no conflict of interest. Publisher Copyright: {\textcopyright} 2017, Springer-Verlag GmbH Germany and ESICM.",
year = "2017",
month = sep,
day = "1",
doi = "10.1007/s00134-017-4896-8",
language = "English (US)",
volume = "43",
pages = "1352--1365",
journal = "Intensive Care Medicine",
issn = "0342-4642",
publisher = "Springer Verlag",
number = "9",
}