Abstract
A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 328-333 |
| Number of pages | 6 |
| Journal | Allergy: European Journal of Allergy and Clinical Immunology |
| Volume | 70 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2015 |
Keywords
- allergens
- allergic sensitization
- genes for atopy
- poly-sensitization
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology