TY - JOUR
T1 - The mammalian urine concentrating mechanism
T2 - Hypotheses and uncertainties
AU - Layton, Anita T.
AU - Layton, Harold E.
AU - Dantzler, William H.
AU - Pannabecker, Thomas L.
PY - 2009/8
Y1 - 2009/8
N2 - The urine concentrating mechanism of the mammalian kidney, which can produce a urine that is substantially more concentrated than blood plasma during periods of water deprivation, is one of the enduring mysteries in traditional physiology. Owing to the complex lateral and axial relationships of tubules and vessels, in both the outer and inner medulla, the urine concentrating mechanism may only be fully understood in terms of the kidney's three-dimensional functional architecture and its implications for preferential interactions among tubules and vessels
AB - The urine concentrating mechanism of the mammalian kidney, which can produce a urine that is substantially more concentrated than blood plasma during periods of water deprivation, is one of the enduring mysteries in traditional physiology. Owing to the complex lateral and axial relationships of tubules and vessels, in both the outer and inner medulla, the urine concentrating mechanism may only be fully understood in terms of the kidney's three-dimensional functional architecture and its implications for preferential interactions among tubules and vessels
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U2 - 10.1152/physiol.00013.2009
DO - 10.1152/physiol.00013.2009
M3 - Review article
C2 - 19675356
SN - 1548-9213
VL - 24
SP - 250
EP - 256
JO - Physiology
JF - Physiology
IS - 4
ER -