@article{7aca1a5b99fc4f1cb71f7f8f1ac0671f,
title = "The next big questions in cancer research",
abstract = "Our understanding of tumorigenesis and cancer progression as well as clinical therapies for different cancer types have evolved dramatically in recent years. However, even with this progress, there are big challenges for scientists and oncologists to tackle, ranging from unpacking the molecular and cellular mechanisms involved to therapeutics and biomarker development to quality of life in the aftermath of therapy. In this article, we asked researchers to comment on the questions that they think are important to address in the coming years.",
author = "Sherene Loi and Jeffrey Settleman and Joyce, {Johanna A.} and Pramesh, {C. S.} and Rene Bernards and Jia Fan and Merchant, {Juanita L.} and Javid Moslehi and Sellers, {William R.}",
note = "Funding Information: R.B. is a shareholder of Agendia and Oncosence, is a member of the board of directors for and has received research funding from Lixte Biotechnology holdings, and receives research funding from Heparegenix GmbH. J.A.J. has received honoraria for speaking at research symposia organized by Bristol Meyers Squibb and Glenmark Pharmaceuticals and currently serves on the scientific advisory board of Pionyr Immunotherapeutics. S.L. receives research funding to her institution from Novartis, Bristol Meyers Squibb, Merck, Puma Biotechnology, Eli Lilly, Nektar Therapeutics, Astra Zeneca, and Seattle Genetics; has acted as consultant (not compensated) to Seattle Genetics, Novartis, Bristol Meyers Squibb, Merck, AstraZeneca, Eli Lilly, Pfizer, Gilead Therapeutics, and Roche-Genentech; and has acted as consultant (paid to her institution) to Aduro Biotech, Novartis, GlaxoSmithKline, Roche-Genentech, Astra Zeneca, Silverback Therapeutics, G1 Therapeutics, PUMA Biotechnologies, Pfizer, Gilead Therapeutics, Seattle Genetics, Daiichi Sankyo, Merck, Amunix, Tallac Therapeutics, Eli Lilly, and Bristol Meyers Squibb. S.L. is supported by the National Breast Cancer Foundation of Australia Endowed Chair and the Breast Cancer Research Foundation, New York. J.M. has served on advisory boards for Bristol-Myers Squibb, Takeda, AstraZeneca, Myovant, Kurome Therapeutics, Kiniksa Pharmaceuticals, Daiichi Sankyo, CRC Oncology, BeiGene, Prelude Therapeutics, TransThera Sciences, and Cytokinetics. J.M. is supported by the NIH (R01HL141466, R01HL155990, R01HL156021, and R01HL160688). J.M. has patents pending related to the treatment of immune-related adverse events including ICI-myocarditis. W.R.S. is a Board or SAB member and holds equity in Ideaya Biosciences, Civetta Therapeutics, Red Ridge Bio, 2Seventy Bio, and Scorpion Therapeutics; has consulted for Array, Astex, Epidarex Capital, Ipsen, Merck Pharmaceuticals, Pierre Fabre, Sanofi, Servier, and Syndax Pharmaceuticals; and receives research funding from Pfizer, Merck, Bristol-Myers, Boehringer-Ingelheim, Ideaya Biosciences, Calico Biosciences, and Ridgeline Discovery. W.R.S. is a co-patent holder on EGFR mutation diagnostic patents. J.S. is an employee of Pfizer, Inc. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",
year = "2023",
month = apr,
day = "13",
doi = "10.1016/j.cell.2023.01.037",
language = "English (US)",
volume = "186",
pages = "1523--1527",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "8",
}