The Omnipresence of DYRK1A in Human Diseases

Estelle Deboever; Alessandra Fistrovich; Christopher Hulme; Travis Dunckley

doi:10.3390/ijms23169355

The Omnipresence of DYRK1A in Human Diseases

Estelle Deboever, Alessandra Fistrovich, Christopher Hulme, Travis Dunckley

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.

Original language	English (US)
Article number	9355
Journal	International journal of molecular sciences
Volume	23
Issue number	16
DOIs	https://doi.org/10.3390/ijms23169355
State	Published - Aug 2022

Keywords

DYRK1A
cancers
diabetes
heart diseases
neurodegenerative diseases
protein kinase
viral infections

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Access to Document

10.3390/ijms23169355

Cite this

@article{6b535dcf143143bbbfcba7d8b0d47052,

title = "The Omnipresence of DYRK1A in Human Diseases",

abstract = "The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.",

keywords = "DYRK1A, cancers, diabetes, heart diseases, neurodegenerative diseases, protein kinase, viral infections",

author = "Estelle Deboever and Alessandra Fistrovich and Christopher Hulme and Travis Dunckley",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = aug,

doi = "10.3390/ijms23169355",

language = "English (US)",

volume = "23",

journal = "International journal of molecular sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "16",

}

TY - JOUR

T1 - The Omnipresence of DYRK1A in Human Diseases

AU - Deboever, Estelle

AU - Fistrovich, Alessandra

AU - Hulme, Christopher

AU - Dunckley, Travis

PY - 2022/8

Y1 - 2022/8

N2 - The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.

AB - The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.

KW - DYRK1A

KW - cancers

KW - diabetes

KW - heart diseases

KW - neurodegenerative diseases

KW - protein kinase

KW - viral infections

UR - http://www.scopus.com/inward/record.url?scp=85137126806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85137126806&partnerID=8YFLogxK

U2 - 10.3390/ijms23169355

DO - 10.3390/ijms23169355

M3 - Review article

C2 - 36012629

SN - 1661-6596

VL - 23

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 16

M1 - 9355

ER -

The Omnipresence of DYRK1A in Human Diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this