Tissue engineering a bioartificial pancreas based on transformed endocrine cells

Thanassis Sambanis; Klearchos K. Papas; Evangelos Tziampazis; Robert C. Long; Ioannis Constantinidis

Tissue engineering a bioartificial pancreas based on transformed endocrine cells

Thanassis Sambanis, Klearchos K. Papas, Evangelos Tziampazis, Robert C. Long, Ioannis Constantinidis

Research output: Contribution to conference › Paper › peer-review

Abstract

The implantation of a functional artificial tissue containing insulin-secreting cells is a promising method for the long-term treatment of diabetes. This approach is rather generic and can be applied to the treatment of other endocrine disorders. A limitation of such application is cell availability. This paper discusses an ongoing study of the bioenergetics and secretory function of insulin-secreting mouse insulinoma BTC3 and recombinant mouse pituitary AtT-20 cells entrapped in calcium alginate/ poly-L-lysine/ alginate beads. Preliminary results indicate good device stability, glucose-responsiveness, and resiliency to stressful conditions. These properties are promising for the future development of a functional bioartificial pancreatic construct.

Original language	English (US)
Pages	211
Number of pages	1
State	Published - 1995
Event	Proceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA Duration: Jun 28 1995 → Jul 2 1995

Other

Other	Proceedings of the 1995 Bioengineering Conference
City	Beever Creek, CO, USA
Period	6/28/95 → 7/2/95

ASJC Scopus subject areas

General Engineering

Cite this

@conference{2ce9b793d4e646b49c947410e0f8b9d5,

title = "Tissue engineering a bioartificial pancreas based on transformed endocrine cells",

abstract = "The implantation of a functional artificial tissue containing insulin-secreting cells is a promising method for the long-term treatment of diabetes. This approach is rather generic and can be applied to the treatment of other endocrine disorders. A limitation of such application is cell availability. This paper discusses an ongoing study of the bioenergetics and secretory function of insulin-secreting mouse insulinoma BTC3 and recombinant mouse pituitary AtT-20 cells entrapped in calcium alginate/ poly-L-lysine/ alginate beads. Preliminary results indicate good device stability, glucose-responsiveness, and resiliency to stressful conditions. These properties are promising for the future development of a functional bioartificial pancreatic construct.",

author = "Thanassis Sambanis and Papas, {Klearchos K.} and Evangelos Tziampazis and Long, {Robert C.} and Ioannis Constantinidis",

year = "1995",

language = "English (US)",

pages = "211",

note = "Proceedings of the 1995 Bioengineering Conference ; Conference date: 28-06-1995 Through 02-07-1995",

}

TY - CONF

T1 - Tissue engineering a bioartificial pancreas based on transformed endocrine cells

AU - Sambanis, Thanassis

AU - Papas, Klearchos K.

AU - Tziampazis, Evangelos

AU - Long, Robert C.

AU - Constantinidis, Ioannis

PY - 1995

Y1 - 1995

N2 - The implantation of a functional artificial tissue containing insulin-secreting cells is a promising method for the long-term treatment of diabetes. This approach is rather generic and can be applied to the treatment of other endocrine disorders. A limitation of such application is cell availability. This paper discusses an ongoing study of the bioenergetics and secretory function of insulin-secreting mouse insulinoma BTC3 and recombinant mouse pituitary AtT-20 cells entrapped in calcium alginate/ poly-L-lysine/ alginate beads. Preliminary results indicate good device stability, glucose-responsiveness, and resiliency to stressful conditions. These properties are promising for the future development of a functional bioartificial pancreatic construct.

AB - The implantation of a functional artificial tissue containing insulin-secreting cells is a promising method for the long-term treatment of diabetes. This approach is rather generic and can be applied to the treatment of other endocrine disorders. A limitation of such application is cell availability. This paper discusses an ongoing study of the bioenergetics and secretory function of insulin-secreting mouse insulinoma BTC3 and recombinant mouse pituitary AtT-20 cells entrapped in calcium alginate/ poly-L-lysine/ alginate beads. Preliminary results indicate good device stability, glucose-responsiveness, and resiliency to stressful conditions. These properties are promising for the future development of a functional bioartificial pancreatic construct.

UR - http://www.scopus.com/inward/record.url?scp=0029226581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029226581&partnerID=8YFLogxK

M3 - Paper

SP - 211

T2 - Proceedings of the 1995 Bioengineering Conference

Y2 - 28 June 1995 through 2 July 1995

ER -

Tissue engineering a bioartificial pancreas based on transformed endocrine cells

Abstract

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ASJC Scopus subject areas

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