Towards rapid DMA sequencing: Detecting single-stranded DNA with a solid-state nanopore

Hao Yan; Bingqian Xu

doi:10.1002/smll.200500464

Towards rapid DMA sequencing: Detecting single-stranded DNA with a solid-state nanopore

Hao Yan, Bingqian Xu

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO₂. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.

Original language	English (US)
Pages (from-to)	310-312
Number of pages	3
Journal	Small
Volume	2
Issue number	3
DOIs	https://doi.org/10.1002/smll.200500464
State	Published - Mar 2006

Keywords

DNA
Nanopores
Sequencing
Single-molecule detection

ASJC Scopus subject areas

General Chemistry
Engineering (miscellaneous)
Biotechnology
General Materials Science
Biomaterials

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10.1002/smll.200500464

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abstract = "Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO2. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.",

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AU - Xu, Bingqian

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AB - Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO2. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.

KW - DNA

KW - Nanopores

KW - Sequencing

KW - Single-molecule detection

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Towards rapid DMA sequencing: Detecting single-stranded DNA with a solid-state nanopore

Abstract

Keywords

ASJC Scopus subject areas

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