Tumor inhibitory agents from Vauquelinia corymbosa (rosaceae)

E. R. Trumbull; E. Bianchi; D. J. Eckert; R. M. Wiedhopf; J. R. Cole

doi:10.1002/jps.2600650938

Tumor inhibitory agents from Vauquelinia corymbosa (rosaceae)

E. R. Trumbull, E. Bianchi, D. J. Eckert, R. M. Wiedhopf, J. R. Cole

Pharmacy Practice and Science

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The chloroform extract of Vauquelinia corymbosa Correa has shown activity against the P‐388 lymphocytic leukemia test system. The constituents responsible for this activity were identified as uvaol, ursolic acid, and betulinic acid. Their identity was proven by melting point; mixed melting point; elemental analysis; IR, PMR, and mass spectra; and preparation of derivatives.

Original language	English (US)
Pages (from-to)	1407-1408
Number of pages	2
Journal	Journal of pharmaceutical sciences
Volume	65
Issue number	9
DOIs	https://doi.org/10.1002/jps.2600650938
State	Published - Sep 1976

Keywords

Antitumor agents, potential—uvaol, ursolic acid, and betulinic acid isolated from leaves and stems of Vauquelinia corymbosa, screened
Vauquelinia corymbosa—chloroform extract of leaves and stems, uvaol, ursolic acid, and betulinic acid isolated, screened for antitumor activity

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600650938

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title = "Tumor inhibitory agents from Vauquelinia corymbosa (rosaceae)",

abstract = "The chloroform extract of Vauquelinia corymbosa Correa has shown activity against the P‐388 lymphocytic leukemia test system. The constituents responsible for this activity were identified as uvaol, ursolic acid, and betulinic acid. Their identity was proven by melting point; mixed melting point; elemental analysis; IR, PMR, and mass spectra; and preparation of derivatives.",

keywords = "Antitumor agents, potential—uvaol, ursolic acid, and betulinic acid isolated from leaves and stems of Vauquelinia corymbosa, screened, Vauquelinia corymbosa—chloroform extract of leaves and stems, uvaol, ursolic acid, and betulinic acid isolated, screened for antitumor activity",

author = "Trumbull, {E. R.} and E. Bianchi and Eckert, {D. J.} and Wiedhopf, {R. M.} and Cole, {J. R.}",

note = "Funding Information: Received September 15, 1975, from the Life Sciences Diuision, Stanford Research Institute, Menlo Park, CA 94025 Accepted for publication December 1,1975. Supported by US. Army Medical Research and Development Command Contract DADA 17-70-C-0112 (W. A. Skinner) and DADA-70-C-0190( H. I. Maibach). * Present address: Division of Dermatology, School of Medicine, University of California, San Francisco Medical Center, San Francisco, CA 94143 To whom inquiries should be directed.",

year = "1976",

month = sep,

doi = "10.1002/jps.2600650938",

language = "English (US)",

volume = "65",

pages = "1407--1408",

journal = "Journal of pharmaceutical sciences",

issn = "0022-3549",

publisher = "John Wiley and Sons Inc.",

number = "9",

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T1 - Tumor inhibitory agents from Vauquelinia corymbosa (rosaceae)

AU - Trumbull, E. R.

AU - Bianchi, E.

AU - Eckert, D. J.

AU - Wiedhopf, R. M.

AU - Cole, J. R.

N1 - Funding Information: Received September 15, 1975, from the Life Sciences Diuision, Stanford Research Institute, Menlo Park, CA 94025 Accepted for publication December 1,1975. Supported by US. Army Medical Research and Development Command Contract DADA 17-70-C-0112 (W. A. Skinner) and DADA-70-C-0190( H. I. Maibach). * Present address: Division of Dermatology, School of Medicine, University of California, San Francisco Medical Center, San Francisco, CA 94143 To whom inquiries should be directed.

PY - 1976/9

Y1 - 1976/9

N2 - The chloroform extract of Vauquelinia corymbosa Correa has shown activity against the P‐388 lymphocytic leukemia test system. The constituents responsible for this activity were identified as uvaol, ursolic acid, and betulinic acid. Their identity was proven by melting point; mixed melting point; elemental analysis; IR, PMR, and mass spectra; and preparation of derivatives.

AB - The chloroform extract of Vauquelinia corymbosa Correa has shown activity against the P‐388 lymphocytic leukemia test system. The constituents responsible for this activity were identified as uvaol, ursolic acid, and betulinic acid. Their identity was proven by melting point; mixed melting point; elemental analysis; IR, PMR, and mass spectra; and preparation of derivatives.

KW - Antitumor agents, potential—uvaol, ursolic acid, and betulinic acid isolated from leaves and stems of Vauquelinia corymbosa, screened

KW - Vauquelinia corymbosa—chloroform extract of leaves and stems, uvaol, ursolic acid, and betulinic acid isolated, screened for antitumor activity

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DO - 10.1002/jps.2600650938

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JO - Journal of pharmaceutical sciences

JF - Journal of pharmaceutical sciences

IS - 9

ER -

Tumor inhibitory agents from Vauquelinia corymbosa (rosaceae)

Abstract

Keywords

ASJC Scopus subject areas

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