Ultrasound-induced sonoporation with the aid of magnetic nanoparticles

Pavlos Anastasiadis; John S. Allen; Terry Matsunaga; Joachim Bertram; Peter K. Weber; Stefan Moisyadi

doi:10.1109/ULTSYM.2012.0513

Ultrasound-induced sonoporation with the aid of magnetic nanoparticles

Pavlos Anastasiadis, John S. Allen, Terry Matsunaga, Joachim Bertram, Peter K. Weber, Stefan Moisyadi

Medical Imaging

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Targeted gene and drug delivery has untapped potential for the treatment of a wide range of pathological conditions. The recent advancements in ultrasound contrast agents (UCAs) including their ability to target regions of interest (ROI) with high specificity makes them ideal for a range of both in vitro and in vivo studies. This work investigates gene expression enhancement by a novel combination of nanosized magnetic particles (MagTag®) and cationic UCAs (cUCAs). The cUCAs have been studied alone and in combination with the MATra-A reagent (Iba Life Sciences, Goettingen, Germany), that uses activated magnetic fields for the delivery of nucleic acids into the cell nucleus.

Original language	English (US)
Title of host publication	2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages	2052-2054
Number of pages	3
DOIs	https://doi.org/10.1109/ULTSYM.2012.0513
State	Published - 2012
Event	2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany Duration: Oct 7 2012 → Oct 10 2012

Publication series

Name	IEEE International Ultrasonics Symposium, IUS

Other

Other	2012 IEEE International Ultrasonics Symposium, IUS 2012
Country/Territory	Germany
City	Dresden
Period	10/7/12 → 10/10/12

Keywords

gene delivery
magnetic-assisted transfection
piggyBac plasmid
sonoporation
ultrasound contrast agents

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2012.0513

Cite this

Anastasiadis, P, Allen, JS, Matsunaga, T, Bertram, J, Weber, PK & Moisyadi, S 2012, Ultrasound-induced sonoporation with the aid of magnetic nanoparticles. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6562554, IEEE International Ultrasonics Symposium, IUS, pp. 2052-2054, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 10/7/12. https://doi.org/10.1109/ULTSYM.2012.0513

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abstract = "Targeted gene and drug delivery has untapped potential for the treatment of a wide range of pathological conditions. The recent advancements in ultrasound contrast agents (UCAs) including their ability to target regions of interest (ROI) with high specificity makes them ideal for a range of both in vitro and in vivo studies. This work investigates gene expression enhancement by a novel combination of nanosized magnetic particles (MagTag{\textregistered}) and cationic UCAs (cUCAs). The cUCAs have been studied alone and in combination with the MATra-A reagent (Iba Life Sciences, Goettingen, Germany), that uses activated magnetic fields for the delivery of nucleic acids into the cell nucleus.",

keywords = "gene delivery, magnetic-assisted transfection, piggyBac plasmid, sonoporation, ultrasound contrast agents",

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AU - Allen, John S.

AU - Matsunaga, Terry

AU - Bertram, Joachim

AU - Weber, Peter K.

AU - Moisyadi, Stefan

PY - 2012

Y1 - 2012

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KW - gene delivery

KW - magnetic-assisted transfection

KW - piggyBac plasmid

KW - sonoporation

KW - ultrasound contrast agents

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Ultrasound-induced sonoporation with the aid of magnetic nanoparticles

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

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