TY - JOUR
T1 - Virulence from the rhizosphere
T2 - ecology and evolution of Burkholderia pseudomallei-complex species
AU - French, Christopher T.
AU - Bulterys, Philip L.
AU - Woodward, Cora L.
AU - Tatters, Avery O.
AU - Ng, Ken R.
AU - Miller, Jeff F.
N1 - Funding Information: This work was supported by the Defense Threat Reduction Agency (DTRA) under awards HDTRA1-17-1-0015 to CTF and HDTRA1-11-1-003 to JFM, the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) award AI137181 to CTF, the NIH Pacific Southwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases (PSWRCE) under award U54 AI065359 to JFM. PLB received support FROM NIH fellowship F30AI118342, the UCLA-Caltech Medical Scientist Training Program (MSTP) ( T32GM008042 ), and a Paul and Daisy Soros Fellowship for New Americans . Publisher Copyright: © 2020 Elsevier Ltd
PY - 2020/4
Y1 - 2020/4
N2 - Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) cause the often-lethal infectious diseases melioidosis and glanders, respectively. Curiously, closely related species within the Bp complex share a nearly identical arsenal of virulence traits, yet are harmless to humans. Clues to the origin of virulence in this group can be found in their genetics and ecology. As a resident of the rhizosphere, Bp faces competition for nutrients and predation by other organisms. Adaptation over millennia has enabled Bp to accumulate mechanisms that overlap in their ability to promote fitness in the environment and virulence in mammals. Here, we review the ecology of Bp and its range of virulence attributes, and offer hypotheses on the evolution of virulence in the Bp complex which are relevant to other environmental pathogens.
AB - Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) cause the often-lethal infectious diseases melioidosis and glanders, respectively. Curiously, closely related species within the Bp complex share a nearly identical arsenal of virulence traits, yet are harmless to humans. Clues to the origin of virulence in this group can be found in their genetics and ecology. As a resident of the rhizosphere, Bp faces competition for nutrients and predation by other organisms. Adaptation over millennia has enabled Bp to accumulate mechanisms that overlap in their ability to promote fitness in the environment and virulence in mammals. Here, we review the ecology of Bp and its range of virulence attributes, and offer hypotheses on the evolution of virulence in the Bp complex which are relevant to other environmental pathogens.
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U2 - https://doi.org/10.1016/j.mib.2019.12.004
DO - https://doi.org/10.1016/j.mib.2019.12.004
M3 - Review article
C2 - 32028234
SN - 1369-5274
VL - 54
SP - 18
EP - 32
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -