ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

George G. Chen; Ursula P.F. Chan; Long Chuan Bai; King Yip Fung; Art Tessier; Ann K.Y. To; Juanita L. Merchant; Paul B.S. Lai

doi:10.1016/j.canlet.2009.03.024

ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

George G. Chen, Ursula P.F. Chan, Long Chuan Bai, King Yip Fung, Art Tessier, Ann K.Y. To, Juanita L. Merchant, Paul B.S. Lai

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.

Original language	English (US)
Pages (from-to)	52-58
Number of pages	7
Journal	Cancer Letters
Volume	283
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2009.03.024
State	Published - Sep 28 2009
Externally published	Yes

Keywords

Caspase-6
Cell cycle
Hepatocellular carcinoma
Proliferation
ZBP-89
p53

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2009.03.024

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title = "ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest",

abstract = "ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.",

keywords = "Caspase-6, Cell cycle, Hepatocellular carcinoma, Proliferation, ZBP-89, p53",

author = "Chen, {George G.} and Chan, {Ursula P.F.} and Bai, {Long Chuan} and Fung, {King Yip} and Art Tessier and To, {Ann K.Y.} and Merchant, {Juanita L.} and Lai, {Paul B.S.}",

note = "Funding Information: This work was supported by the Research Grants Council of the Hong Kong SAR. No: CUHK4551/05 M to PBSL and GGC, and Public Heath Service Grant R01 DK-55732 to JLM.",

year = "2009",

month = sep,

day = "28",

doi = "10.1016/j.canlet.2009.03.024",

language = "English (US)",

volume = "283",

pages = "52--58",

journal = "Cancer Letters",

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T1 - ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

AU - Chen, George G.

AU - Chan, Ursula P.F.

AU - Bai, Long Chuan

AU - Fung, King Yip

AU - Tessier, Art

AU - To, Ann K.Y.

AU - Merchant, Juanita L.

AU - Lai, Paul B.S.

N1 - Funding Information: This work was supported by the Research Grants Council of the Hong Kong SAR. No: CUHK4551/05 M to PBSL and GGC, and Public Heath Service Grant R01 DK-55732 to JLM.

PY - 2009/9/28

Y1 - 2009/9/28

N2 - ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.

AB - ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.

KW - Caspase-6

KW - Cell cycle

KW - Hepatocellular carcinoma

KW - Proliferation

KW - ZBP-89

KW - p53

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DO - 10.1016/j.canlet.2009.03.024

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SN - 0304-3835

VL - 283

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EP - 58

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

Abstract

Keywords

ASJC Scopus subject areas

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